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Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

8 Feb 2025

Abstract excerpt

BACKGROUND: The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel diseases (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe. METHODS: This study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, the investigation focused on admixture-informed...

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PMID: 39923740
DOI: 10.1016/j.ebiom.2025.105591

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