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Article

Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.

Gastroenterology - 1 May 2026

Beecham Ashley H, McGovern Dermot P B, Brugger Steven W, Davis Mary F, Torres Esther A, Gomez Lissette, Li Dalin, Lopez-Marte Paola, Daly Mark J, Stevens Christine, Yang Shaohong, Sinha Sweta, Mengesha Emebet, Leavitt James, Damas Oriana M, Quintero Maria A, Targan Stephan R, Rabizadeh Shervin, Sabic Ksenija, Cho Judy H, Abreu Maria T, McCauley Jacob L, Haritunians Talin

Abstract excerpt

BACKGROUND & AIMS: Genetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41661118
DOI: 10.1053/j.gastro.2025.11.007
PMCID: PMC13140159

Genes

TYROBP
GAD2
IL23R
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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