Admixture as a source for HLA variation in Neolithic European farming communities.

doi:10.1186/s13059-025-03509-6

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Article

Admixture as a source for HLA variation in Neolithic European farming communities.

Genome biology - 28 Feb 2025

da Silva Nicolas Antonio, Özer Onur, Haller-Caskie Magdalena, Chen Yan-Rong, Kolbe Daniel, Schade-Lindig Sabine, Wahl Joachim, Berszin Carola, Francken Michael, Görner Irina, Schierhold Kerstin, Pechtl Joachim, Grupe Gisela, Rinne Christoph, Müller Johannes, Lenz Tobias L, Nebel Almut, Krause-Kyora Ben

Abstract excerpt

BACKGROUND: The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, from around 6200 years before present. The influence of this admixture event on variation in the immune-relevant human leukocyte antigen (HLA) region is understudied....

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Topics

Humans
HLA Antigens
Haplotypes
Male
Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Variation

Chromosomes, Human, Y

Farmers

Agriculture

Female

Germany

White People

Genetics, Population

History, Ancient

Human Migration

Source

Open in PubMed Open full text

Identifiers

PMID: 40022192
DOI: 10.1186/s13059-025-03509-6
PMCID: PMC11869582

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