Article
Heterozygosity for IL23R p.Arg381Gln confers a protective effect not only against Crohn's disease but also ulcerative colitis.
Alimentary pharmacology & therapeutics - 1 Oct 2007
Büning C, Schmidt H H-J, Molnar T, De Jong D J, Fiedler T, Bühner S, Sturm A, Baumgart D C, Nagy F, Lonovics J, Drenth J P H, Landt O, Nickel R, Büttner J, Lochs H, Witt H
Abstract excerpt
BACKGROUND: A recent study reported that a non-synonymous single nucleotide polymorphism (rs11209026, p.Arg381Gln) located in the IL23R gene is a protective marker for inflammatory bowel disease. AIM: To analyse the frequency of p.Arg381Gln in three independent European inflammatory bowel disease cohorts and to evaluate how this variant influences disease behaviour. METHODS: We assessed a European cohort of 919...
Topics
- Adult
- Cohort Studies
- Colitis, Ulcerative
- Colonic Neoplasms
- Crohn Disease
- Female
- Genetic Carrier Screening