Neolithic introgression of <i>IL23R</i> -related protection against chronic inflammatory bowel diseases in modern Europeans

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe. <h4>Methods</h4> This study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, the investigat...

Topics

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• Case-Control Studies
• Colitis, Ulcerative
• Crohn Disease
• Gene Frequency
• Genetic Loci
• Genome-Wide Association Study
• Polymorphism, Single Nucleotide
• Risk Factors

Identifiers and source

Literature Corpus work

7c4c6b61-bbb3-5323-bbf7-38342218ef47

DOI

10.1101/2024.08.06.606840