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The JAK2 46/1 haplotype influences PD-L1 expression

7 Feb 2025

Abstract excerpt

ABSTRACT: Although described more than a decade ago, the mechanism by which the JAK2 46/1 haplotype increases the risk of developing JAK2-mutated myeloproliferative neoplasms (MPNs) remains unexplained. Inflammation and immunity are linked to MPN development and thus could be relevant to the mechanism by which 46/1 mediates its effect. Here, we show that programmed death-1 receptor ligand (PD-L1) expression is...

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PMID: 39919265
DOI: 10.1182/blood.2023023787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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