Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.

Nature genetics - 1 Apr 2009

Olcaydu Damla, Harutyunyan Ashot, Jäger Roland, Berg Tiina, Gisslinger Bettina, Pabinger Ingrid, Gisslinger Heinz, Kralovics Robert

Abstract excerpt

Genome-wide association studies have identified a number of new disease susceptibility loci that represent haplotypes defined by numerous SNPs. SNPs within a disease-associated haplotype are thought to influence either the expression of genes or the sequence of the proteins they encode. In a series of investigations of the JAK2 gene in myeloproliferative neoplasms, we uncovered a new property of haplotypes that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematologic Neoplasms

Share to Heterozygote

Share to Homozygote

Share to Janus Kinase 2

Share to Polycythemia Vera

Share to Thrombocythemia, Essential

Source

Identifiers

PMID: 19287385
DOI: 10.1038/ng.341

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms.PMID 19287385Read ↗

JAK2 46/1 (GGCC) Haplotype: A Biomarker for Oncogenesis, Risk Stratification, and Drug Resistance in Myeloproliferative NeoplasmsSemantic proximity Read ↗

A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.Semantic proximity Read ↗

Genetic and epigenetic complexity in myeloproliferative neoplasms.Semantic proximity Read ↗

Inherited predisposition to myeloproliferative neoplasmsSemantic proximity Read ↗

The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome.Semantic proximity Read ↗

The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.Semantic proximity Read ↗

Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis.Semantic proximity Read ↗

Germline genetic variants that predispose to myeloproliferative neoplasms and hereditary myeloproliferative phenotypes.Semantic proximity Read ↗

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.Semantic proximity Read ↗

Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasmsSemantic proximity Read ↗

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms.Semantic proximity Read ↗

A primer on genomic and epigenomic alterations in the myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.