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Article

PD-L1 overexpression correlates with JAK2-V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms.

American journal of hematology - 1 Apr 2022

Milosevic Feenstra Jelena D, Jäger Roland, Schischlik Fiorella, Ivanov Daniel, Eisenwort Gregor, Rumi Elisa, Schuster Michael, Gisslinger Bettina, Machherndl-Spandl Sigrid, Bettelheim Peter, Krauth Maria-Theresa, Keil Felix, Bock Christoph, Cazzola Mario, Gisslinger Heinz, Kralovics Robert, Valent Peter

Abstract excerpt

Myeloproliferative neoplasms (MPN) are chronic stem cell disorders characterized by enhanced proliferation of myeloid cells, immune deregulation, and drug resistance. JAK2 somatic mutations drive the disease in 50-60% and CALR mutations in 25-30% of cases. Published data suggest that JAK2-V617F-mutated MPN cells express the resistance-related checkpoint PD-L1. By applying RNA-sequencing on granulocytes of 113 MPN...

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PMID: 35015307
DOI: 10.1002/ajh.26461
PMCID: PMC9306481

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