Article
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.
Nature genetics - 1 Apr 2009
Jones Amy V, Chase Andrew, Silver Richard T, Oscier David, Zoi Katerina, Wang Y Lynn, Cario Holger, Pahl Heike L, Collins Andrew, Reiter Andreas, Grand Francis, Cross Nicholas C P
Abstract excerpt
Chronic myeloproliferative neoplasms (MPNs) are a group of related conditions characterized by the overproduction of cells from one or more myeloid lineages. More than 95% of cases of polycythemia vera, and roughly half of essential thrombocythemia and primary myelofibrosis acquire a unique somatic 1849G>T JAK2 mutation (encoding V617F) that is believed to be a critical driver of excess proliferation. We report...
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