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Article

JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.

International journal of hematology - 1 Mar 2013

Tanaka Mayumi, Yujiri Toshiaki, Ito Shunsuke, Okayama Naoko, Takahashi Toru, Shinohara Kenji, Azuno Yoichi, Nawata Ryouhei, Hinoda Yuji, Tanizawa Yukio

Abstract excerpt

Myeloproliferative neoplasms (MPNs) constitute a group of phenotypically diverse chronic myeloid malignancies, characterized by clonal hematopoiesis and excessive production of terminally differentiated myeloid blood cells. The MPNs include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), most of which are characterized by a somatic point mutation, V617F, in the janus...

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Source

Identifiers

PMID: 23430670
DOI: 10.1007/s12185-013-1295-y

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.PMID 23430670Read ↗

JAK2 46/1 haplotype is associated with JAK2 V617F--positive myeloproliferative neoplasms in Brazilian patients.Semantic proximity Read ↗

[Relationship between V617F mutation and 46/1 haplotype in JAK2 gene in patients with chronic myeloproliferative diseases and frequencies of 46/1 haplotype in different Chinese nationalities].Semantic proximity Read ↗

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.Semantic proximity Read ↗

Association of JAK2 Haplotype GGCC_46/1 with the Response to Onco-Drug in MPNs Patients Positive for JAK2V617F MutationSemantic proximity Read ↗

The C allele of JAK2 rs4495487 is an additional candidate locus that contributes to myeloproliferative neoplasm predisposition in the Japanese population.Semantic proximity Read ↗

The G allele of the JAK2 rs10974944 SNP, part of JAK2 46/1 haplotype, is strongly associated with JAK2 V617F-positive myeloproliferative neoplasms.Semantic proximity Read ↗

JAK2 46/1 (GGCC) Haplotype: A Biomarker for Oncogenesis, Risk Stratification, and Drug Resistance in Myeloproliferative NeoplasmsSemantic proximity Read ↗

The Contribution of JAK2 46/1 Haplotype in the Predisposition to Myeloproliferative Neoplasms.Semantic proximity Read ↗

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Relationship between the 46/1 haplotype of the JAK2 gene and the JAK2 mutational status and allele burden, the initial findings, and the survival of patients with myelofibrosis.Semantic proximity Read ↗

The JAK2 GGCC (46/1) Haplotype in Myeloproliferative Neoplasms: Causal or Random?Semantic proximity Read ↗

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