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Article

The Contribution of JAK2 46/1 Haplotype in the Predisposition to Myeloproliferative Neoplasms.

International journal of molecular sciences - 20 Oct 2022

Paes Jhemerson, Silva George A V, Tarragô Andréa M, Mourão Lucivana P de Souza

Abstract excerpt

Haplotype 46/1 (GGCC) consists of a set of genetic variations distributed along chromosome 9p.24.1, which extend from the Janus Kinase 2 gene to Insulin like 4. Marked by four jointly inherited variants (rs3780367, rs10974944, rs12343867, and rs1159782), this haplotype has a strong association with the development of BCR-ABL1-negative myeloproliferative neoplasms (MPNs) because it precedes the acquisition of the...

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Identifiers

PMID: 36293440
DOI: 10.3390/ijms232012582
PMCID: PMC9604447

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