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Article

Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes.

Scientific reports - 6 Feb 2025

Yao Xiaoling, Cai Xin, Zhang Shaoqin, Yang Yuzheng, Yang Xiangyan, Ma Wukai, Jiang Zong

Abstract excerpt

This study aims to explore the causal relationships between serum uric acid level and pulmonary arterial hypertension (PAH) using the Mendelian randomization (MR) approach, and to assess the therapeutic impacts of urate-lowering drugs on PAH. Utilizing published genome-wide association study (GWAS) data, we applied MR and colocalization analysis to assess the link between serum uric acid levesl and PAH across...

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Share to PAH gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gout, Hyperuricemia, Uric Acid

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Pulmonary Arterial Hypertension

Share to Pulmonary Hypertension Research and Treatments

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Source

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Identifiers

PMID: 39915571
DOI: 10.1038/s41598-025-88887-4
PMCID: PMC11802783

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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