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Mendelian randomization analysis of blood uric acid and risk of preeclampsia: based on GWAS and eQTL data.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Dec 2025

Wang Jiao, Liu Xiaohu, Fu Youmou, Zhu Baosheng, Zhang Jinman

Abstract excerpt

BACKGROUND: The causal association between blood uric acid and preeclampsia (Preeclampsia, PE) has not been conclusively established based on the literature reviewed to date. This bi-directional Mendelian randomization study aimed to investigate the bi-directional causal association between blood uric acid concentration and PE at different genetic levels. METHODS: Pooled data on preeclampsia (sample size =...

Topics

Humans
Female
Uric Acid
Mendelian Randomization Analysis
Pregnancy
Genome-Wide Association Study
Pre-Eclampsia
Quantitative Trait Loci
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

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PMID: 39746786
DOI: 10.1080/14767058.2024.2443673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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