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Article

A phenome-wide association and factorial Mendelian randomization study on the repurposing of uric acid-lowering drugs for cardiovascular outcomes.

European journal of epidemiology - 1 Aug 2024

Wang Lijuan, Mesa-Eguiagaray Ines, Campbell Harry, Wilson James F, Vitart Veronique, Li Xue, Theodoratou Evropi

Abstract excerpt

Uric acid has been linked to various disease outcomes. However, it remains unclear whether uric acid-lowering therapy could be repurposed as a treatment for conditions other than gout. We first performed both observational phenome-wide association study (Obs-PheWAS) and polygenic risk score PheWAS (PRS-PheWAS) to identify associations of uric acid levels with a wide range of disease outcomes. Then, trajectory...

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Identifiers

PMID: 38992218
DOI: 10.1007/s10654-024-01138-0
PMCID: PMC11410910

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