Serum uric acid levels as a causal factor in hypertension: Insights from Mendelian randomization analysis

Abstract excerpt

BACKGROUND: Hyperuricemia and hypertension are prevalent chronic diseases that often co-occur. While numerous observational studies suggest an association between serum uric acid (SUA) levels and hypertension, the causal nature of this relationship remains unresolved due to confounding and reverse causation. This study systematically investigates the causal association between SUA levels and hypertension risk...