DNA repair pathways in the mitochondria.

doi:10.1016/j.dnarep.2025.103814

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Article

DNA repair pathways in the mitochondria.

DNA repair - 1 Feb 2025

King Dillon E, Copeland William C

Abstract excerpt

Mitochondria contain their own small, circular genome that is present in high copy number. The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain. Mutations in the mitochondrial genome are associated with a wide range of mitochondrial diseases and the maintenance and replication of mtDNA is crucial to cellular health. Despite the importance of maintaining mtDNA genomic...

Topics

Humans
Mitochondria
DNA, Mitochondrial
DNA Repair
Animals
DNA Damage
Mutation
Neoplasms
Genome, Mitochondrial

Source

Open in PubMed Open full text

Identifiers

PMID: 39914164
DOI: 10.1016/j.dnarep.2025.103814
PMCID: PMC11848857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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