Article

Mitochondrial DNA Damage and Diseases

2015-07-01

Abstract excerpt

Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage. One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA d...

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Literature Corpus work: 45e0200b-e714-5a89-9448-b6218462b48d
DOI: 10.12688/f1000research.6665.1

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