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Article

Significance of Mitochondria DNA Mutations in Diseases.

Advances in experimental medicine and biology - 1 Jan 2017

Zhu Zhenhua, Wang Xiangdong

Abstract excerpt

Mitochondria are essential double-membraned cytoplasmic organelles to support aerobic respiration and produce cellular energy by oxidative phosphorylation (OXPHOS). Mitochondrial functions are controlled by mitochondrial (mtDNA) and nuclear genomes (nDNA). Mutations of mtDNA result in mitochondrial dysfunction and multisystem diseases through compromising OXPHOS function directly by a point mutation or a...

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PMID: 29178079
DOI: 10.1007/978-981-10-6674-0_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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