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Mitochondrial DNA replication and repair defects: Clinical phenotypes and therapeutic interventions.

Biochimica et biophysica acta. Bioenergetics - 1 Jun 2022

Roy Abhipsa, Kandettu Amoolya, Ray Swagat, Chakrabarty Sanjiban

Abstract excerpt

Mitochondria is a unique cellular organelle involved in multiple cellular processes and is critical for maintaining cellular homeostasis. This semi-autonomous organelle contains its circular genome - mtDNA (mitochondrial DNA), that undergoes continuous cycles of replication and repair to maintain the mitochondrial genome integrity. The majority of the mitochondrial genes, including mitochondrial replisome and...

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PMID: 35341749
DOI: 10.1016/j.bbabio.2022.148554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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