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Article

Mitochondrial genome stability in human: understanding the role of DNA repair pathways.

The Biochemical journal - 26 Mar 2021

Dahal Sumedha, Raghavan Sathees C

Abstract excerpt

Mitochondria are semiautonomous organelles in eukaryotic cells and possess their own genome that replicates independently. Mitochondria play a major role in oxidative phosphorylation due to which its genome is frequently exposed to oxidative stress. Factors including ionizing radiation, radiomimetic drugs and replication fork stalling can also result in different types of mutations in mitochondrial DNA (mtDNA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33740046
DOI: 10.1042/BCJ20200920

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