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Mitochondrial DNA Repair in Neurodegenerative Diseases and Ageing

27 Sept 2022

Abstract excerpt

Mitochondria are the only organelles, along with the nucleus, that have their own DNA. Mitochondrial DNA (mtDNA) is a double-stranded circular molecule of ~16.5 kbp that can exist in multiple copies within the organelle. Both strands are translated and encode for 22 tRNAs, 2 rRNAs, and 13 proteins. mtDNA molecules are anchored to the inner mitochondrial membrane and, in association with proteins, form a structure...

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PMID: 36232693
DOI: 10.3390/ijms231911391

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