Article
Mitochondrial DNA repair and damage tolerance.
Frontiers in bioscience (Landmark edition) - 1 Jan 2017
Stein Alexis, Sia Elaine A
Abstract excerpt
The accurate maintenance of mitochondrial DNA (mtDNA) is required in order for eukaryotic cells to assemble a functional electron transport chain. This independently-maintained genome relies on nuclear-encoded proteins that are imported into the mitochondria to carry out replication and repair processes. Decades of research has made clear that mitochondria employ robust and varied mtDNA repair and damage...
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