Article

Integrating multi-ancestry common and rare variant mapping accelerates therapeutic target discovery

2026-07-08

Abstract excerpt

Integrating human genetics into therapeutic discovery accelerates drug development. However, ancestral biases in historical cohorts have left critical functional variation largely uncharted. Here, we leverage the diverse NIH All of Us Research Program to conduct comprehensive common- and rare-variant association analyses for 624 quantitative traits across 369,655 ancestrally diverse individuals. We identified 6,1...

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Literature Corpus work: 7ddc63a8-ffa3-52a2-a890-a7c3df1a61af
DOI: 10.64898/2026.06.25.26356239

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