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Article

Transfer Learning Prediction of Early Exposures and Genetic Risk Score on Adult Obesity in Two Minority Cohorts.

Prevention science : the official journal of the Society for Prevention Research - 1 Feb 2025

Chen Wenying, Liu Yuxin, Zhang Shuo, Jiang Zhou, Wang Ting, Huang Shuiping, Zeng Ping

Abstract excerpt

Due to ethnic heterogeneity in genetic architecture, genetic risk score (GRS) constructed within the European population generally possesses poor portability in underrepresented non-European populations, but substantial genetic similarity exists across diverse ancestral groups. We here explore the prediction performance of early exposures and GRS on body mass index (BMI) through leveraging genetic similarity...

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PMID: 39913075
DOI: 10.1007/s11121-025-01781-3

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