Article

Multiethnic Polygenic Risk Prediction in Diverse Populations through Transfer Learning

2022-03-30

Abstract excerpt

Polygenic risk scores (PRS) leverage the genetic contribution of an individual’s genotype to a complex trait by estimating disease risk. Traditional PRS prediction methods are predominantly for European population. The accuracy of PRS prediction in non-European populations is diminished due to much smaller sample size of genome-wide association studies (GWAS). In this article, we introduced a novel method to const...

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Literature Corpus work: c33a642f-5329-53cd-ba2b-d0c839fc7e68
DOI: 10.1101/2022.03.30.486333

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