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MRBEE-TL: improving causal effect estimation in multi-ancestry multivariable Mendelian randomization with transfer learning.

Genome biology - 31 Mar 2026

Yang Yihe, Zhu Xiaofeng

Abstract excerpt

Multivariable Mendelian randomization has been largely applied to individuals of European ancestry, due to the larger sample sizes available in European GWAS. We introduce MRBEE-TL, one of the first multi-ancestry multivariable Mendelian randomization methods, which combines transfer learning with bias-corrected estimating equations to improve power in underpowered ancestries and to assess cross-ancestry...

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PMID: 41913286
DOI: 10.1186/s13059-026-04051-9
PMCID: PMC13159297

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