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Article

Hypoxic Secretome and Exosomes Derived From Human Glioblastoma Cells (U87MG) Promote Protumorigenic Phenotype of Microglia in Vitro.

Journal of cellular biochemistry - 1 Feb 2025

Pancholi Sangati, Shah Ritvi, Bose Utsav, Yadav Ankit, Murukan Karthik, Pillai Prakash

Abstract excerpt

Glioblastoma multiforme (GBM), a highly heterogeneous CNS tumor known for its highest incidence rates and poor prognosis has shown limited success in the therapies due to hypoxia-driving immune-suppression in the tumor microenvironment (TME). Emerging evidence highlights the involvement of tumor cell-derived exosomes in tumor-associated microglia polarization via transfer of exosomal onco-proteins and miRNAs....

Read the complete abstract on PubMed

Topics

Humans
Brain Neoplasms
CD163 Antigen
Cell Hypoxia
Cell Line, Tumor
Exosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Glioblastoma

Interleukin-10

Mannose Receptor

Microglia

Phagocytosis

Phenotype

RNA, Long Noncoding

Secretome

Signal Transduction

STAT3 Transcription Factor

Tumor Microenvironment

Source

Identifiers

PMID: 39905831
DOI: 10.1002/jcb.70002

Genes

CD163
IL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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