Article

Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis

2022-07-15

Abstract excerpt

<title>Abstract</title> <p>Background Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells. The mechanism by which these exosomes modify the phenotype of microglia in the tumor microenvironment to further determine the fate of irradiated glioblastoma cells remains to be elucidated. Methods We erected the co-culture sy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1425c3be-a265-5c82-8af2-5306ce28d174
DOI: 10.21203/rs.3.rs-1789882/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axisDOI 10.21203/rs.3.rs-1789882/v1Read

Radiotherapy induces specific miRNA expression profiles in glioblastoma exosomesSemantic proximity Read

Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance.Semantic proximity Read

Progenitor Cells, Microglia, and Non-coding RNAs: Orchestrators of Glioblastoma Pathogenesis and Therapeutic ResistanceSemantic proximity Read

Molecular profiles and immunomodulatory activities of glioblastoma-derived exosomesSemantic proximity Read

Preclinical Evidence of STAT3 Inhibitor, Pacritinib, Overcomes Temozolomide Resistance via Down-Regulating miR-21-enriched Exosomes from M2 Glioblastoma-Associated MacrophagesSemantic proximity Read

Arginase-1+ Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression.Semantic proximity Read

Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-Like Macrophage ActivationSemantic proximity Read

Irradiation-induced M1 Microglia Affect Brain Metastatic Colonization of A549 Cell Lines via miR-9/CDH1 AxisSemantic proximity Read

Harnessing the Cross-talk between Tumor Cells and Tumor-associated Macrophages with a Nano-drug for modulation of Glioblastoma Immune MicroenvironmentSemantic proximity Read

Systemic delivery of a CXCR4-CXCL12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapySemantic proximity Read

Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor- associated macrophages in glioblastomaSemantic proximity Read

The Integrated Analysis of Differential Long Non-Coding RNAs Expression Profiles in Extracellular Vesicles Derived From Chemoradioresistant and Parental Nasopharyngeal Carcinoma CellsSemantic proximity Read