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Article

Arginase-1+ Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression.

International journal of molecular sciences - 2 Jun 2020

Azambuja Juliana H, Ludwig Nils, Yerneni Saigopalakrishna S, Braganhol Elizandra, Whiteside Theresa L

Abstract excerpt

Interactions between tumor cells and tumor-associated macrophages (TAMs) are critical for glioblastoma progression. The TAMs represent up to 30% of the glioblastoma mass. The role of TAMs in tumor progression and in the mechanisms underlying tumor growth remain unclear. Using an in vitro model resembling the crosstalk between macrophages and glioblastoma cells, we show that glioblastoma-derived exosomes (GBex)...

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Identifiers

PMID: 32498400
DOI: 10.3390/ijms21113990
PMCID: PMC7312363

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