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Article

EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment.

Journal of neuroinflammation - 13 Nov 2017

Yin Yatao, Qiu Shuwei, Li Xiangpen, Huang Bo, Xu Yun, Peng Ying

Abstract excerpt

BACKGROUND: Glioblastoma multiforme (GBM) induces tumor immunosuppression through interacting with tumor-infiltrating microglia or macrophages (TAMs) with an unclear pathogenesis. Enhancer of zeste homolog 2 (EZH2) is abundant in GBM samples and cell lines and is involved in GBM proliferation, cell cycle, and invasion, whereas its association with innate immune response is not yet reported. Herein, the aim of...

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Identifiers

PMID: 29132376
DOI: 10.1186/s12974-017-0993-4
PMCID: PMC5684749

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