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Article

Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2.

Human genomics - 30 Jan 2025

Malaspina Patrizia, Jodice Carla, Ciminelli Bianca Maria, Biancolella Michela, Colona Vito Luigi, Latini Andrea, Leonardis Francesca, Rogliani Paola, Novelli Antonio, Novelli Giuseppe, Novelletto Andrea

Abstract excerpt

BACKGROUND: The Immunoglobulin Heavy Chain (IGH) genomic region is responsible for the production of circulating antibodies and warrants careful investigation for its association with COVID-19 characteristics. Multiple allelic variants within and across different IGH gene segments form a limited set of haplotypes. Previous studies have shown associations between some of these haplotypes and clinical outcomes of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39885568
DOI: 10.1186/s40246-025-00719-8
PMCID: PMC11780896

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IGH

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