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Article

Variation of the 3'RR1 HS1.2 Enhancer and Its Genomic Context.

Genes - 29 Jun 2024

Jodice Carla, Malaspina Patrizia, Ciminelli Bianca Maria, Martinez-Labarga Cristina, Biancolella Michela, Novelli Giuseppe, Novelletto Andrea

Abstract excerpt

In humans, the HS1.2 enhancer in the Ig heavy-chain locus is modular, with length polymorphism. Previous studies have shown the following features for this variation: (i) strong population structuring; (ii) association with autoimmune diseases; and (iii) association with developmental changes in Ig expression. The HS1.2 region could then be considered as a contributor to inter-individual diversity in humoral...

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Identifiers

PMID: 39062635
DOI: 10.3390/genes15070856
PMCID: PMC11275349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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