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Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity

1 Mar 2025

Abstract excerpt

Vaccine immunogenicity is influenced by the vaccinee's genetic background. Here, we perform a genome-wide association study of vaccine-induced SARS-CoV-2-specific immunoglobulin G (IgG) antibody titers and T cell immune responses in 1,559 mRNA-1273 and 537 BNT162b2 vaccinees of Japanese ancestry. SARS-CoV-2-specific antibody titers are associated with the immunoglobulin heavy chain (IGH) and major...

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Identifiers

PMID: 40043710
DOI: 10.1016/j.xgen.2025.100783

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