Article
Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity.
Frontiers in immunology - 1 Jan 2023
Hardt Uta, Corcoran Martin M, Narang Sanjana, Malmström Vivianne, Padyukov Leonid, Karlsson Hedestam Gunilla B
Abstract excerpt
Immunoglobulin heavy chain (IGH) germline gene variations influence the B cell receptor repertoire, with resulting biological consequences such as shaping our response to infections and altering disease susceptibilities. However, the lack of information on polymorphism frequencies in the IGH loci at the population level makes association studies challenging. Here, we genotyped a pilot group of 30 individuals with...
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