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Article

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.

Nature immunology - 1 Oct 2024

Sun Wenbo, Yang Tingyu, Sun Fengming, Liu Panhong, Gao Ji, Lan Xianmei, Xu Wei, Pang Yuhong, Li Tong, Li Cuifeng, Liang Qingtai, Chen Haoze, Liu Xiaohang, Tan Wenting, Zhu Huanhuan, Wang Fang, Cheng Fanjun, Zhai Weiwei, Kim Han-Na, Zhang Jingren, Zhang Linqi, Lu Lu, Xi Qiaoran, Deng Guohong, Huang Yanyi, Jin Xin, Chen Xiangjun, Liu Wanli

Abstract excerpt

Evolutionary pressures sculpt population genetics, whereas immune adaptation fortifies humans against life-threatening organisms. How the evolution of selective genetic variation in adaptive immune receptors orchestrates the adaptation of human populations to contextual perturbations remains elusive. Here, we show that the G396R coding variant within the human immunoglobulin G1 (IgG1) heavy chain presents a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39261722
DOI: 10.1038/s41590-024-01944-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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