Sex-Specific HLA Alleles Contribute to the Modulation of COVID-19 Severity.

doi:10.3390/ijms252313198

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Article

Sex-Specific HLA Alleles Contribute to the Modulation of COVID-19 Severity.

International journal of molecular sciences - 8 Dec 2024

Spartano Serena, Faggiano Maria Vittoria, Guidi Giovanna, D'Ambrosio Pino, Vaisfeld Alessandro, Novelli Agnese, Falqui Salvatore, Cingolani Antonella, Lambertenghi Lorenza, Visentin Alessandro, Azzini Annamaria, Righi Elda, Trecarichi Enrico Maria, Mazzitelli Maria, Coletti Silvano, Mous Jan, Rademacher Thomas W, Torti Carlo, Tacconelli Evelina, Fantoni Massimo, Cauda Roberto, Tiziano Francesco Danilo

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, responsible for Coronavirus Disease 2019 (COVID-19), exhibits a spectrum of clinical manifestations, ranging from asymptomatic to severe pulmonary dysfunction or death. The variability in COVID-19 severity has largely been attributed to the host's genetic characteristics, suggesting a polygenic genetic architecture, without significant strong...

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PMID: 39684907
DOI: 10.3390/ijms252313198
PMCID: PMC11642212

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