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Article

Notch dimerization provides robustness against environmental insults and is required for vascular integrity.

PloS one - 1 Jan 2025

Preusse Kristina, Cochran Kim, Dai Quanhui, Kopan Raphael

Abstract excerpt

The Notch intracellular domain (NICD) regulates gene expression during development and homeostasis in a transcription factor complex that binds DNA either as monomer, or cooperatively as dimers. Mice expressing Notch dimerization-deficient (NDD) alleles of Notch1 and Notch2 have defects in multiple tissues that are sensitized to environmental insults. Here, we report that cardiac phenotypes and DSS (Dextran...

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Topics

Animals
Mice
Receptor, Notch1
Receptor, Notch2
Protein Multimerization
Dextran Sulfate
Receptors, Notch

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39854367
DOI: 10.1371/journal.pone.0311353

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