Article
Autoimmune disorder phenotypes in Hvcn1-deficient mice.
The Biochemical journal - 1 Mar 2013
Sasaki Mari, Tojo Akihiro, Okochi Yoshifumi, Miyawaki Nana, Kamimura Daisuke, Yamaguchi Akihito, Murakami Masaaki, Okamura Yasushi
Abstract excerpt
H(v) channels (voltage-gated proton channels) are expressed in blood cells, microglia and some types of epithelial cells. In neutrophils H(v) channels regulate the production of reactive oxygen species through regulation of membrane potential and intracellular pH. H(v) channels have also been suggested to play a role in sperm physiology in the human. However, the functions of the Hv channel at the whole-body...
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