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Contribution of oxidative stress to endothelial dysfunction in hereditary hemorrhagic telangiectasia

13 Feb 2015

Abstract excerpt

Oxidative stress causes endothelial dysfunction and is implicated in the pathogenesis of cardiovascular diseases. Our studies suggested that reactive oxygen species (ROS) play a crucial role in hereditary hemorrhagic telangiectasia (HHT) disease, a vascular dysplasia affecting 1 in 5,000-8,000 people. Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1) genes are responsible for HHT1 and HHT2...

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PMID: 25763011
DOI: 10.3389/fgene.2015.00034

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