Article
A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease).
Communications biology - 1 Jan 2019
Raza Abbas, Xie Zhihui, Chan Eunice C, Chen Wei-Sheng, Scott Linda M, Robin Eisch A, Krementsov Dimitry N, Rosenberg Helene F, Parikh Samir M, Blankenhorn Elizabeth P, Teuscher Cory, Druey Kirk M
Abstract excerpt
The systemic capillary leak syndrome (SCLS, Clarkson disease) is a disorder of unknown etiology characterized by recurrent episodes of vascular leakage of proteins and fluids into peripheral tissues, resulting in whole-body edema and hypotensive shock. The pathologic mechanisms and genetic basis for SCLS remain elusive. Here we identify an inbred mouse strain, SJL, which recapitulates cardinal features of SCLS,...
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