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Article

The role of notch in modeling and maintaining the vasculature

1 Jan 2005

Abstract excerpt

The Notch proteins encompass a family of transmembrane receptors that have been highly conserved through evolution as mediators of cell fate, and are comprised of 4 members in mammals (Notch1 to Notch4). Following intra cellular processing of the full-length protein, Notch is expressed at the cell surface as a heterodimeric receptor. Engagement by ligand results in a 2-step cleavage of the Notch heterodimer,...

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PMID: 15759046
DOI: 10.1139/y04-125

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