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Article

Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.

PLoS genetics - 1 Sept 2012

Moribe Hiroki, Konakawa Ryouji, Koga Daisuke, Ushiki Tatsuo, Nakamura Kuniaki, Mekada Eisuke

Abstract excerpt

Reactive oxygen species (ROS) are toxic but essential molecules responsible for host defense and cellular signaling. Conserved NADPH oxidase (NOX) family enzymes direct the regulated production of ROS. Hydrogen peroxide (H(2)O(2)) generated by dual oxidases (DUOXs), a member of the NOX family, is crucial for innate mucosal immunity. In addition, H(2)O(2) is required for cellular signaling mediated by protein...

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PMID: 23028364
DOI: 10.1371/journal.pgen.1002957
PMCID: PMC3447965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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