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Article

Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma.

Oral oncology - 1 May 2015

Raju Sharat C, Hauff Samantha J, Lemieux Aaron J, Orosco Ryan K, Gross Andrew M, Nguyen Linda T, Savariar Elamprakash, Moss William, Whitney Michael, Cohen Ezra E, Lippman Scott M, Tsien Roger Y, Ideker Trey, Advani Sunil J, Nguyen Quyen T

Abstract excerpt

OBJECTIVE: Patients with head and neck squamous cell carcinoma (HNSCC) containing TP53 mutation and 3p deletion ("double-hit") have poorer prognosis compared to patients with either event alone ("single-hit"). The etiology for worse clinical outcomes in patients with "double-hit" cancers is unclear. We compared radiosensitivity of cell lines containing both TP53 mutations and deletion of Fragile Histidine Triad...

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Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 3

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Source

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Identifiers

PMID: 25735654
DOI: 10.1016/j.oraloncology.2015.01.014
PMCID: PMC4427339

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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