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Article

Comprehensive Genomic and Transcriptomic Analysis of Three Synchronous Primary Tumours and a Recurrence from a Head and Neck Cancer Patient.

International journal of molecular sciences - 15 Jul 2021

Bresadola Luisa, Weber David, Ritzel Christoph, Löwer Martin, Bukur Valesca, Akilli-Öztürk Özlem, Becker Julia, Mehanna Hisham, Schrörs Barbara, Vascotto Fulvia, Sahin Ugur, Kong Anthony

Abstract excerpt

Synchronous primary malignancies occur in a small proportion of head and neck squamous cell carcinoma (HNSCC) patients. Here, we analysed three synchronous primaries and a recurrence from one patient by comparing the genomic and transcriptomic profiles among the tumour samples and determining the recurrence origin. We found remarkable levels of heterogeneity among the primary tumours, and through the patterns of...

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Identifiers

PMID: 34299215
DOI: 10.3390/ijms22147583
PMCID: PMC8305204

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