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Article

Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the post-treatment surveillance of head and neck cancer.

Oncotarget - 20 Sept 2016

van Ginkel Joost H, de Leng Wendy W J, de Bree Remco, van Es Robert J J, Willems Stefan M

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCC) form a large heterogeneous group of tumors and have a relatively poor outcome in advanced cases. Revealing the underlying genetic mutations in HNSCC facilitates the development of diagnostic biomarkers, which might lead to improved diagnosis and post treatment surveillance. We retrospectively analyzed mutational hotspots using targeted next-generation sequencing...

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Source

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Identifiers

PMID: 27528217
DOI: 10.18632/oncotarget.11196
PMCID: PMC5308673

Genes

HRAS
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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