Article
Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules.
Virchows Archiv : an international journal of pathology - 1 Jun 2016
Pelosi Giuseppe, Pellegrinelli Alessio, Fabbri Alessandra, Tamborini Elena, Perrone Federica, Settanni Giulio, Busico Adele, Picciani Benedetta, Testi Maria Adele, Militti Lucia, Maisonneuve Patrick, Valeri Barbara, Sonzogni Angelica, Proto Claudia, Garassino Marina, De Braud Filippo, Pastorino Ugo
Abstract excerpt
While pulmonary adenocarcinoma (ADC) is morphologically heterogeneous, little is known about intra-tumor gene mutation heterogeneity (ITH). We therefore subjected 20 ADC nodules, 5 mutated for EGFR and 5 for KRAS, 5 with an ALK translocation, and 5 wild type (WT) for these alterations, to unsupervised next-generation sequencing of tumor regions from diverse architectural patterns. When 2 or more different gene...
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