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Article

Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness.

Nature communications - 3 May 2016

Nguyen Alexander, Yoshida Mitsukuni, Goodarzi Hani, Tavazoie Sohail F

Abstract excerpt

Individual cells within a tumour can exhibit distinct genetic and molecular features. The impact of such diversification on metastatic potential is unknown. Here we identify clonal human breast cancer subpopulations that display different levels of morphological and molecular diversity. Highly variable subpopulations are more proficient at metastatic colonization and chemotherapeutic survival. Through single-cell...

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Identifiers

PMID: 27138336
DOI: 10.1038/ncomms11246
PMCID: PMC4857405

Genes

SNRNP40

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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