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ISOLATE: a computational strategy for identifying the primary origin of cancers using high-throughput sequencing

19 Jun 2009

Abstract excerpt

MOTIVATION: One of the most deadly cancer diagnoses is the carcinoma of unknown primary origin. Without the knowledge of the site of origin, treatment regimens are limited in their specificity and result in high mortality rates. Though supervised classification methods have been developed to predict the site of origin based on gene expression data, they require large numbers of previously classified tumors for...

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PMID: 19542156
DOI: 10.1093/bioinformatics/btp378

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