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Article

Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome.

The Journal of pathology - 1 Feb 2025

Trahearn Nicholas, Sakr Chirine, Banerjee Abhirup, Lee Seung Hyun, Baker Ann-Marie, Kocher Hemant M, Angerilli Valentina, Morano Federica, Bergamo Francesca, Maddalena Giulia, Intini Rossana, Cremolini Chiara, Caravagna Giulio, Graham Trevor, Pietrantonio Filippo, Lonardi Sara, Fassan Matteo, Sottoriva Andrea

Abstract excerpt

Colorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our understanding, it is critical that the TME is studied systematically within clinically annotated patient cohorts with long-term follow-up. Here we studied the TME in three clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 39788558
DOI: 10.1002/path.6378
PMCID: PMC11717494

Genes

BRAF
EGFR
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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