Back to search

Article

Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers

2024-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Predicting the progression of solid cancers based solely on genetics is challenging due to the influence of the tumor microenvironment (TME). For colorectal cancer (CRC), tumors deficient in mismatch repair (dMMR) are more immune infiltrated than mismatch repair proficient (pMMR) tumors and have better prognosis following resection. Here we quantify features of the CRC TME by combining spatial p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8cfd6faf-0979-596a-9261-08651a7207d5
DOI
10.1101/2024.09.24.614701
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancersDOI 10.1101/2024.09.24.614701
Immunogenomic profile of colorectal cancer response to immune checkpoint blockadeSemantic proximity
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancerSemantic proximity
Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesisSemantic proximity
Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy responseSemantic proximity
Characterization of immune cell populations in the tumor microenvironment of colorectal cancer using high definition spatial profilingSemantic proximity
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts.Semantic proximity
Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling ApproachSemantic proximity
Spatial Dynamics Links PD-L1 and Tumor-Associated Macrophage–Enriched Niches to Immune and Mesenchymal States in Microsatellite Stable Colorectal CancerSemantic proximity
Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancerSemantic proximity
High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancerSemantic proximity
Spatial transcriptome unveils a discontinuous inflammatory pattern in proficient mismatch repair colorectal adenocarcinomaSemantic proximity
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal CancerSemantic proximity
Select a neighboring publication to make it the new centre.